Internalization of interleukin 2 is mediated by the beta chain of the high-affinity interleukin 2 receptor.
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چکیده
منابع مشابه
Internalization of interleukin 2 is mediated by the beta chain of the high-affinity interleukin 2 receptor
High-affinity IL-2-R correspond to a membrane receptor complex composed of two different IL-2-binding proteins, the Tac antigen (alpha chain) and a 70-75 kD beta chain. Using cell lines that express either the alpha or the beta protein, we demonstrate that IL-2 internalization occurs when ligand is bound to the isolated beta chain, but not when it is bound to the isolated alpha chain. The kinet...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1987
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.165.4.1201